What treatment is going to be offered for this patient?

Journal Club Issue #4


On this image, this patient presents with intraretinal fluid and hyperreflectivity in the deep retina. This patient was diagnosed with wet AMD and offered treatment with an anti-VEGF compound.

In general, there is a tremendous burden on patients, their family members and medical practices to treat wet AMD.

In today’s journal club we review the LADDER study, a phase 2 randomized clinical trial published in the journal Ophthalmology. This study evaluated a new reservoir system called a Port Delivery System for the slow release of ranibizumab.

In this journal club's accompanying 12 min. video, Dr. Sharma will review:

  • Learn how the Port Delivery System works
  • The efficacy of this delivery system
  • The risk profile of the device


Campochiaro PA, Marcus DM, Awh CC, et al. The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial. Ophthalmology. 2019;126(8):1141-1154. doi:10.1016/j.ophtha.2019.03.036