OCT Academy

Journal Club - Previous

2. Blurred vision in 74-year-old man

What mineral has been shown to be at the center of these lesions?

Tip #2


In this image, there is a collection of both small hard drusen in the perivascular area of the macular and softer drusen (video). The softer drusen appear greyish-white in coloration, versus the highly refractile hard drusen. This patient was diagnosed with dry AMD.

Recent research from the Age-related Eye Disease Study (AREDS) has linked calcium supplementation to a lower incident risk of advanced AMD (Tisdale et al. JAMA Ophthalmology, 2019).

In this journal club's accompanying 17 min. video, Dr. Sharma will review:

  • The difference between prevalence and incidence
  • The biologic plausibility of calcium being linked to drusen
  • What to tell your AMD patients on calcium


Alanna K. Tisdale, MD, MPH; Elvira Agrón, MA; Sarah B. Sunshine, MD; et al. Association of Dietary and Supplementary Calcium Intake With Age-Related Macular Degeneration. JAMA Ophthalmol. 2019;137(5):543-550.


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