A 72-year-old presents with blurred vision. Why?

Tip #246


Here we can see significant changes in the deeper retina. There is discontinuity in the ellipsoid zone (EZ), and a deep elevation. This elevation is heterogeneous in nature and is located beneath the RPE. The patient was known to have active multiple myeloma.

The patient was diagnosed with suspected uveal infiltration with multiple myeloma.

In this tip's accompanying 15 min. video, we'll review:

  • The differential diagnosis of deeper retinal elevations
  • Pathogenesis of multiple myeloma and how it causes ocular manifestations
  • Ocular manifestations of multiple myeloma
Tip #246 Analysis


In a patient presenting with a retinal vein occlusion or signs of orbital disease, always consider the possibility of multiple myeloma.

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